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Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries.
ACS Medicinal Chemistry Letters 2017 August 11
From a screening campaign that included mixture-based libraries containing more than 6 million compounds, a lead series of bis-cyclic guanidines was identified as the most promising. Lead optimization resulted in the identification of potent (IC50 < 500 nM) and selective compounds within this series as well as potent and selective monoguanidines.
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