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Dopamine-modified highly porous hydroxyapatite microtube networks with efficient near-infrared photothermal effect, enhanced protein adsorption and mineralization performance.
Colloids and Surfaces. B, Biointerfaces 2017 November 2
In the last decade, the porous hydroxyapatite (HAP) scaffold has been investigated for the application in tissue engineering owing to its good bioactivity and high biocompatibility. In this work, the dopamine-modified highly porous hydroxyapatite microtube three-dimensional (3-D) networks with efficient near-infrared photothermal effect, enhanced protein adsorption and mineralization performance have been prepared through a facile method. The dopamine-modified highly porous HAP networks exhibit ultrahigh porosity (90.6%), uniform pore distribution, interconnected pore structure and outstanding mechanical properties. After being modified with dopamine, the protein adsorption amount, cell attachment performance, and mineralization ability of the dopamine-modified highly porous HAP network can be greatly improved. In addition, the as-prepared dopamine-modified highly porous HAP networks exhibit good biocompatibility, excellent near-infrared photothermal effect, and good mechanical properties. The experimental results indicate that the dopamine-modified highly porous HAP networks are promising for various applications.
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