We have located links that may give you full text access.
Size optimization and in vitro biocompatibility studies of chitosan nanoparticles.
International Journal of Biological Macromolecules 2017 November
Chitosan (CS), an amino polysaccharide has fascinating scientific applications due to its many flexible properties. The advantages of Chitosan tend to increase when it was modified. Thus, in the present research work, to improve the properties of chitosan, it was converted into chitosan nanoparticles (CS-NPs) through the ionic gelation method using sodium tripoyphosphate (TPP) and sodium hexametaphosphate (SHMP) as a crosslinker. The size optimization was done by varying the parameters such as crosslinker concentration, agitation method and rate, agitation time, temperature and drying method. The prepared samples were characterized using FTIR, TGA, XRD, SEM, TEM and DLS. Also the prepared CS-NPs with TPP and SHMP had been evaluated in vitro for determining its hemocompatibility, biodegradability, serum stability, cytotoxicity and cell viability. The results showed the significant participation of all the parameters in obtaining the nanoparticles in 20-30nm and 5-10nm for CS-NPs-TPP air dried and freeze dried samples and around 60-80nm and 20-30nm for CS-NPs-SHMP air dried and freeze dried samples. The in vitro biological studies revealed that the nanoparticles are non-toxic with a good degree of biodegradability, blood compatibility and stability.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app