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Computation-Guided Design of a Stimulus-Responsive Multienzyme Supramolecular Assembly.
Chembiochem : a European Journal of Chemical Biology 2017 October 19
The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane.
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