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Inducing high activity of a thermophilic enzyme at ambient temperatures by directed evolution.
Chemical Communications : Chem Comm 2017 August 23
The long-standing problem of achieving high activity of a thermophilic enzyme at low temperatures and short reaction times with little tradeoff in thermostability has been solved by directed evolution, an alcohol dehydrogenase found in hot springs serving as the catalyst in enantioselective ketone reductions.
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