[A study on the effects of exposure to benzene on the activity of immunoglobulin E].

Objective: To analyze the level of immunoglobulin E (IgE) changes with benzene exposure workers. Methods: Firstly, through occupational health monitoring, 68 hospitalized cases were discovered who were suspected chronic benzene poisoning. Secondly, according to the GBZ68-2013《The diagnosis of occupational benzene poisoning》standard diagnosis and indexing, 68 cases were divided into the benzene poisoning group ( n = 29) and the benzene exposure group ( n =39) . 50 cases of healthy workers without benzene exposure were for the control group. Use the immune luminescence method to detect IgE levels. Thirdly, Case-control study was used, observing IgE changes though the three groups by statistical analysis. Results: Compared with control group, the level of leukocyte、neutrophil and IgE was drop in benzene exposure group with statistically significant ( P <0.05) . Compared with benzene exposure group, IgE of benzene poisoning group was rise, with statistically significant ( P <0.05) , IgE of mild benzene poisoning group rise the most obvious, with statistically significant ( P <0.05) . Compared with benzene exposure group, IgE of moderate benzene poisoning group was drop, without statistically significant ( P >0.05) . Conclusion: Benzene occupational exposure can induce immunosuppression, IgE decreases, and reduces immune surveillance. The response of the IgE level in the mild benzene poisoning patients was significantly elevated, whether it is protective response of the body immune function needs to be studied further investigated.