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JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., INTRAMURAL
Non-invasive intravital imaging of head and neck squamous cell carcinomas in live mice.
Methods : a Companion to Methods in Enzymology 2017 September 2
Head and neck squamous cell carcinoma is one of the most common cancers with a 50% 5-year survival rate. Understanding the mechanisms that control development, progression, and spreading of the tumor to distal sites is of paramount importance to develop effective therapies. Here, we describe a minimally invasive procedure, which enables performing intravital microscopy of the mouse tongue in models for oral cancer and provides structural and dynamic information of the tumors at cellular and subcellular level.
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