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Journal Article
Review
Current Status of HbA1c Biosensors.
Sensors 2017 August 5
Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α-amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements.
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