We have located links that may give you full text access.
COMPARATIVE STUDY
EVALUATION STUDY
JOURNAL ARTICLE
Additional value of the ratio of serum total testosterone to total prostate-specific antigen in the diagnosis of prostate cancer in a Chinese population.
Andrologia 2018 March
We investigated whether serum testosterone and testosterone/prostate-specific antigen ratio (T/PSA) might be prostate cancer (PCa) biomarkers. We retrospectively reviewed 92 patients with benign prostatic hyperplasia (BPH) and 164 patients with PCa treated at Zhongshan Hospital, China (April 2012 to November 2013). The BPH and PCa groups had similar serum total testosterone (median, 15.8 versus 16.3 nmol/L).Compared with the BPH group, the PCa group had higher PSA (16.8 versus 5.1 ng/ml) and lower free/total PSA (9.5% versus 19.3%) and T/PSA (1.37 versus 4.69) (all p < .001).Patients with PCa and PSA ≤20 ng/ml had higher testosterone (17.5 versus 12.9 ng/ml; p = .002) and T/PSA (2.24 versus 0.29; p < .001) than those with PSA >20 ng/ml. Patients with PCa and Gleason score ≤7 had higher testosterone (18.3 versus 14.1 ng/ml; p = .023) and T/PSA (1.93 versus 0.72; p < .001) than those with Gleason score >7. In patients with PSA ≤20 ng/ml, T/PSA was higher in those with BPH than in those with PCa (4.69 versus 2.24; p < .001). ROC curve analysis yielded an AUC of 0.712; for the optimal cut-off of 4.43, specificity and sensitivity were 52% and 97% respectively. T/PSA may improve the accuracy of PCa diagnosis in patients with a PSA level ≤20 ng/ml.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app