CASE REPORTS
JOURNAL ARTICLE
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Multiorgan eosinophilic infiltration after initiation of clozapine therapy: a case report.

BMC Research Notes 2017 July 26
BACKGROUND: The eosinophilic response to clozapine is well described in the literature, causing a variety of responses, from serositis to colitis. However, there are not case reports describing a clozapine-induced marked eosinophilia resulting in multiorgan dysfunction.

CASE PRESENTATION: In this case report, we describe a 24 year old Caucasian male who presented with severe systemic eosinophilia resulting in eosinophilic GI tract infiltration, myocarditis, pericardial and pleural effusions with dramatic improvement following drug withdrawal.

CONCLUSIONS: Clozapine associated eosinophilia should be suspected in the setting of eosinophilic infiltration of multiple organs.

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