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5-Formylcytosine Yields DNA-Protein Cross-Links in Nucleosome Core Particles.

Fengchao Li, Yingqian Zhang, Jing Bai, Marc M Greenberg, Zhen Xi, Chuanzheng Zhou
Journal of the American Chemical Society 2017 August 10
In situ generation of 5-formylcytosine (5fC) in nucleosome core particles (NCPs) reveals that 5fC leads to essential DNA-protein cross-links (DPCs). Mechanistic studies using chemical models and mutated histones demonstrate that DPCs form reversibly between the formyl function of 5fC and primary amines on histones. These results suggest that DPC formation from 5fC in chromatin occurs in addition to its role in DNA demethylation.

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