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Put Your Mark Where Your Damage Is: Acetyl-CoA Production by ACLY Promotes DNA Repair.
Molecular Cell 2017 July 21
In this issue of Molecular Cell, Sivanand et al. (2017) describe the importance for nuclear ACLY-mediated production of acetyl-CoA, which promotes histone acetylation, BRCA1 recruitment, and subsequent HR-mediated DNA repair in response to DNA damage, thus drawing a direct link between DNA repair and cellular metabolism.
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