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JOURNAL ARTICLE
Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells.
Cell Chemical Biology 2017 July 21
In this issue of Cell Chemical Biology,Benoit et al. (2017) report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.
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