The effect of chlorpromazine on intracellular Ca(2+) concentration in macrophages.

Using Fura-2AM microfluorimetry, it was shown for the first time that neuroleptic chlorpromazine causes intracellular Ca(2+) concentration increase in macrophages due to Ca(2+) mobilization from intracellular Ca(2+) stores and subsequent Ca(2+) entry from the external medium. Chlorpromazine-induced Ca(2+) entry is inhibited by La(3+) and 2-aminoethoxydiphenyl borate and is associated with Ca(2+) store depletion.