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A Ligand-Based NMR Screening Approach for the Identification and Characterization of Inhibitors and Promoters of Amyloid Peptide Aggregation.
ChemMedChem 2017 September 8
Over the years a significant amount of effort has been put into the development of rapid and reliable methods to monitor the aggregation dynamics of the β1-42 amyloid peptide in real time. We present an alternative approach based on a suitable reporter or spy molecule and three different NMR experiments: WaterLOGSY, 1 H selective T1 filter, and 19 F T2 filter, for monitoring the initial self-aggregation process kinetics of the β1-42 amyloid peptide and identifying molecules that retard or accelerate the self-aggregation process. Although the proposed method is not a high-throughput assay, it avoids problems associated with interference events that are sometimes observed in fluorescence-based assays.
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