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Defining the role of Lgr5(+) stem cells in colorectal cancer: from basic research to clinical applications.

Masayuki Fujii, Toshiro Sato
Genome Medicine 2017 July 19
Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5(+) intestinal stem cells, providing insights into their roles in homeostasis and cancer.

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