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COMMENT
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
REVIEW
Activated ERK: An Emerging Player in miRNA Downregulation.
Trends in Cancer 2017 March
To date, the mechanisms underlying global downregulation of miRNAs in cancer remain largely unclear. Recent findings indicate that activated ERK can cause widespread miRNA repression through suppressing the major steps of miRNA biogenesis. Here we discuss how ERK signaling globally downregulates miRNAs and how this contributes to tumorigenesis.
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