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Tunable Upper Critical Solution Temperatures for Acrylamide Copolymers with Bile Acid Pendants.
Biomacromolecules 2017 August 15
Acrylamide derivatives of bile acids are chosen as a hydrophobic comonomer to copolymerize with acrylamide via reversible addition and fragmentation chain transfer (RAFT) polymerization to afford a series of copolymers of P(AAm-co-CAA). These copolymers exhibit a sharp and reversible insoluble-soluble transition in water upon heating to a mixing temperature (Tmix ) related to the upper critical solution temperature (UCST). Tmix of these copolymers can be conveniently tuned to a practical temperature range, around 37 °C for biomedical applications. Tmix rises with increasing molar fraction of the bile acid-based acrylamide and increasing concentration of the aqueous solution of the copolymers. The addition of a natural host molecule β-cyclodextrin lowered the Tmix . The insoluble-soluble transition of the copolymers was also evidenced by dynamic light scattering and transmission electron microscopy. The biocompatible nature of the bile acids and β-cyclodextrins may make these copolymers potentially useful for biomedical applications.
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