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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
A study of DNA damage in buccal cells of consumers of well- and/or tap-water using the comet assay: Assessment of occupational exposure to genotoxicants.
Environmental and Molecular Mutagenesis 2017 October
Because of concerns that natural aquifers in the region of Todos Santos (Baja California Sur, Mexico) might be contaminated by organochlorine pesticides and heavy metals, a case-control study was conducted among consumers and non-consumers of well- and/or tap-water to determine risks to human health. This study was based on a genotoxic evaluation of buccal cells using the Comet assay technique. Levels of DNA damage in the consumers group were significantly higher than those of the control group. However, occupational exposure to genotoxicants showed to be the critical factor rather than water consumption. Taking into account the professions of well- and/or tap-water consumers, agricultural workers exposed directly (those who fumigated) or indirectly (those not involved in fumigating) to agrochemicals showed greater genetic damage than controls. This difference persisted even when age, and whether the person smoked or consumed alcoholic drinks were considered. These factors were not associated with the level of genetic damage observed. Chemical analyses of organochlorine pesticides and heavy metals were carried out to evaluate the water quality of wells, faucets, and surface water of canals consumed by the population and/or used for irrigation. High concentrations of α and β endosulfan were detected in water of surface canals. Although our inventory of agrochemicals employed in the region showed the use of products considered carcinogenic and/or mutagenic, they were not detected by the analytical techniques used. Heavy metals (arsenic, mercury, and lead) were detected in water of some wells used for irrigation and human consumption. Environ. Mol. Mutagen. 58:619-627, 2017. © 2017 Wiley Periodicals, Inc.
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