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In vitro investigation of the dose-rate effect on the biological effectiveness of megavoltage X-ray radiation doses.

Radiation therapy is rapidly evolving toward the delivery of higher dose rates to improve cancer treatment. In vitro experiments were performed to investigate the response of 9L and MCF-7 cancer cell lines, exposed to 10MV X-ray radiations. Up to 8Gy was delivered at a dose-rate of 50cGy/min compared to 5Gy/min. The data obtained emphasizes the importance of taking into account not only the physical, but also the radiobiological parameters, when planning a particular cancer treatment.

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