We have located links that may give you full text access.
Variable selection for joint models of multivariate longitudinal measurements and event time data.
Statistics in Medicine 2017 October 31
Joint modeling of longitudinal and survival data has attracted a great deal of attention. Some research has been undertaken to extend the joint model to incorporate multivariate longitudinal measurements recently. However, there is a lack of variable selection methods in the joint modeling of multivariate longitudinal measurements and survival time. In this article, we develop penalized likelihood methods for the selection of longitudinal features in the survival submodel. A multivariate linear mixed effect model is used to model multiple longitudinal processes where random intercepts and slopes serve as essential features of the trajectories. We introduce L1 penalty functions to select both random effects in the survival submodel and off-diagonal elements in the covariance matrix of random effects. An estimation procedure is developed based on Laplace approximation. Our simulations demonstrate excellent selection properties of the proposed procedure. We apply our methods to explore the relationship between mortality and multiple longitudinal processes for end stage renal disease patients on hemodialysis. We find that lower levels of albumin, higher levels of neutrophil-to-lymphocyte ratio, and higher levels of interdialytic weight gain at the beginning of the follow-up time, as well as decrease in predialysis systolic blood pressure and increase of neutrophil-to-lymphocyte ratio over time are associated with higher mortality hazard rates.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app