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Gender dysphoria in Klinefelter's syndrome: three cases.

BACKGROUND: Previous reports have found the incidence of gender dysphoria in Klinefelter's patients greater than in the general male population.

METHODS: A cohort of patients with gender dysphoria was reviewed.

RESULTS: Of the 220 patients with gender dysphoria, three had Klinefelter's syndrome.

CONCLUSIONS: These three reports are further examples of gender dysphoria in Klinefelter's syndrome. The role of biological factors in gender identity is affirmed. Caution is urged in prescribing testosterone.

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