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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
miRNAs in B Cell Development and Lymphomagenesis.
Trends in Molecular Medicine 2017 August
B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that microRNAs (miRNAs) - a class of non-coding RNAs that control gene expression - are involved in the regulation of B cell development and function. We provide here an overview of the current knowledge on the role of miRNAs and their relevant targets in B cell development, B cell activation, and B cell malignant transformation.
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