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Network-based approaches that exploit inferred transcription factor activity to analyze the impact of genetic variation on gene expression.
Current Opinion in Systems Biology 2017 April
Over the past decade, a number of methods have emerged for inferring protein-level transcription factor activities in individual samples based on prior information about the structure of the gene regulatory network. We discuss how this has enabled new methods for dissecting trans-acting mechanisms that underpin genetic variation in gene expression.
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