We have located links that may give you full text access.
Bioactive M(II) complexes of amino acid-based N 3 O donor mixed ligand: in vitro and in silico DNA binding studies.
Journal of Chemical Biology 2017 July
Three novel mixed ligand M(II) complexes, namely [CoL1 L2 Cl2 ] ( 1 ), [CuL1 L2 Cl2 ] ( 2 ), and [ZnL1 L2 Cl2 ] ( 3 ), were synthesized using 1,4-naphthoquinone, L-histidine, and 1,10-phenanthroline as ligands. The ligand framework and the corresponding structural changes on complexation were ascertained based on the results of elemental analysis, conductivity measurements, magnetic behavior, FT-IR, UV-visible, 1 H NMR, 13 C NMR, ESR spectral studies, and ESI mass spectrometry. The biological action of the ligand ( L ) and complexes 1 - 3 such as DNA binding and cleaving ability were studied. Results suggest that the ligand and the complexes could interact with calf thymus-DNA (CT-DNA) via intercalation mode. Additionally, complex 2 displayed potential antioxidant activity in in vitro studies. Docking simulation was performed to position the ligand and the complexes into the active site of BDNA (IBNA) to determine the probable binding mode.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app