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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Bioactivity-guided isolation of chemical constituents against H 2 O 2 -induced neurotoxicity on PC12 from Cimicifuga dahurica (Turcz.) Maxim.
Bioorganic & Medicinal Chemistry Letters 2017 August 2
Three new compounds (1, 6, 9), with six known compounds (2-5, 7-8) were obtained from water-soluble extract of Cimicifuga dahurica (Turcz.) Maxim. by bioactivity-guided isolation. Their structures were elucidated by chemical and spectral analysis, including 1D, 2D NMR data and HRESIMS. H2 O2 -induced neurotoxicity on PC12 cells model were conducted to evaluate the neuro-protective capability of these compounds. The piscidic acid derivatives compounds 4-7 showed marked neuro-protective effect at certain concentration.
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