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Multimodal mechanistic signatures for neurodegenerative diseases (NeuroMMSig): a web server for mechanism enrichment.
Bioinformatics 2017 November 16
Motivation: The concept of a 'mechanism-based taxonomy of human disease' is currently replacing the outdated paradigm of diseases classified by clinical appearance. We have tackled the paradigm of mechanism-based patient subgroup identification in the challenging area of research on neurodegenerative diseases.
Results: We have developed a knowledge base representing essential pathophysiology mechanisms of neurodegenerative diseases. Together with dedicated algorithms, this knowledge base forms the basis for a 'mechanism-enrichment server' that supports the mechanistic interpretation of multiscale, multimodal clinical data.
Availability and implementation: NeuroMMSig is available at https://neurommsig.scai.fraunhofer.de/.
Contact: [email protected].
Supplementary information: Supplementary data are available at Bioinformatics online.
Results: We have developed a knowledge base representing essential pathophysiology mechanisms of neurodegenerative diseases. Together with dedicated algorithms, this knowledge base forms the basis for a 'mechanism-enrichment server' that supports the mechanistic interpretation of multiscale, multimodal clinical data.
Availability and implementation: NeuroMMSig is available at https://neurommsig.scai.fraunhofer.de/.
Contact: [email protected].
Supplementary information: Supplementary data are available at Bioinformatics online.
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