We have located links that may give you full text access.
High need to switch cART or co-medication with the initiation of DAAs in elderly HIV/HCV co-infected patients.
BACKGROUD: To describe the use of non-antiretroviral co-medication and combination antiretroviral therapy (cART) in HIV/hepatitis C virus (HCV) co-infected patients, and to predict the potential for drug-drug interactions (DDIs) with direct-acting antivirals (DAAs) against HCV.
METHODS: This is a retrospective, cross-sectional study, using the Dutch nationwide ATHENA observational HIV cohort database. All patients with a known HIV/HCV co-infection on 1 January 2015 were included. Co-medication and cART registered in the database were listed. The potential for DDIs between DAAs and co-medication/cART were predicted, using https://hep-druginteractions.org. DDIs were categorized as: (1) no clinically relevant DDI; (2) possible DDI; (3) contra-indication; or (4) no information available.
RESULTS: We included 777 patients of whom 488 (63%) used non-antiretroviral co-medication. At risk for a category 2/3 DDI with non-antiretroviral co-medications were 299 patients (38%). Most DDIs were predicted with paritaprevir/ritonavir, ombitasvir ± dasabuvir (47% of the drugs) and least with grazoprevir/elbasvir (11% of the drugs).Concerning cART, daclatasvir/sofosbuvir is the most favourable combination as no cART is contra-indicated with this combination. In genotype 1/4 patients grazoprevir/elbasvir is least favourable as 75% of the patients must alter their cART.
CONCLUSIONS: This study showed that co-medication use in the aging HIV/HCV population is frequent and diverse. There is a high potential for DDIs between DAAs and co-medication/cART.
METHODS: This is a retrospective, cross-sectional study, using the Dutch nationwide ATHENA observational HIV cohort database. All patients with a known HIV/HCV co-infection on 1 January 2015 were included. Co-medication and cART registered in the database were listed. The potential for DDIs between DAAs and co-medication/cART were predicted, using https://hep-druginteractions.org. DDIs were categorized as: (1) no clinically relevant DDI; (2) possible DDI; (3) contra-indication; or (4) no information available.
RESULTS: We included 777 patients of whom 488 (63%) used non-antiretroviral co-medication. At risk for a category 2/3 DDI with non-antiretroviral co-medications were 299 patients (38%). Most DDIs were predicted with paritaprevir/ritonavir, ombitasvir ± dasabuvir (47% of the drugs) and least with grazoprevir/elbasvir (11% of the drugs).Concerning cART, daclatasvir/sofosbuvir is the most favourable combination as no cART is contra-indicated with this combination. In genotype 1/4 patients grazoprevir/elbasvir is least favourable as 75% of the patients must alter their cART.
CONCLUSIONS: This study showed that co-medication use in the aging HIV/HCV population is frequent and diverse. There is a high potential for DDIs between DAAs and co-medication/cART.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app