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Journal Article
Research Support, Non-U.S. Gov't
Atropisomerism in Tertiary Biaryl 2-Amides: A Study of Ar-CO and Ar-Ar' Rotational Barriers.
Journal of Organic Chemistry 2017 July 22
A rotational barrier study was performed on eight tertiary biaryl 2-amides using variable-temperature (VT) NMR and exchange (EXSY) spectroscopy experiments. Seven out of the eight 2-amido-2'-methylbiphenyls with additional 3- and 6-substitution patterns (1-7) were found to have approximately similar rotational barriers (ΔG⧧ Tc = 56.5-67.5 kJ/mol). However, for both 3- and 6-substitution (8), the rotational barrier was found to be significantly higher (ΔG⧧ = 102.6-103.8 kJ/mol). Computational studies performed on all eight compounds gave results in good agreement with the experimental rotational barriers. A transition state in which atropisomerism occurs by a cooperative rotation of the Ar-CO and Ar-Ar' bonds depending on substituent location is proposed.
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