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Diastereoselective [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF 2 HCHN 2 : syntheses of CF 2 H-containing spirooxindoles.

An efficient [3 + 2] cycloaddition of 3-ylideneoxindoles with in situ generated CF2 HCHN2 for the syntheses of spirooxindoles has been developed. This methodology gives access to a range of relatively complex spirooxindoles featuring a CF2 H group and three contiguous stereogenic centers in up to 84% yield and 99 : 1 trans/cis.

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