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Letter
Research Support, Non-U.S. Gov't
Targeted Deletion of an Entire Chromosome Using CRISPR/Cas9.
Molecular Therapy 2017 August 3
CRISPR/Cas9 genome editing can facilitate efficient deletion of genomic region, but it has not been used to delete an entire chromosome. Here, Adikusuma et al. show proof-of-concept for efficient CRISPR-mediated selective chromosome deletion by removing the centromere or shredding the chromosome arm in mouse embryonic stem cells and zygotes.
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