We have located links that may give you full text access.
JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
RESEARCH SUPPORT, NON-U.S. GOV'T
Resting limb muscle perfusion during inspiratory muscle loading in hypoxia and normoxia.
Respiratory Physiology & Neurobiology 2017 October
INTRODUCTION: Fatiguing of respiratory muscles reduces peripheral muscle perfusion. Further, acute hypoxia enhances respiratory muscle fatigue. This study investigated the effects of inspiratory muscle loading (IML) on resting locomotor muscle perfusion in hypoxia compared to normoxia.
METHODS: Ten subjects completed two study days of fatiguing IML (blinded, randomized) in normobaric hypoxia (targeted oxygen saturation 80%) and normoxia, respectively. Contrast-enhanced ultrasound (CEUS) of the gastrocnemius muscle and popliteal doppler ultrasonography were used to monitor muscle perfusion. Based on CEUS and monitored cardiac output, perfusion surrogate parameters (CLPaer and CLPap ) were established.
RESULTS: Muscle perfusion declines early during IML in normoxia (CLPaer : -54±25%, p<0.01; CLPap : -58±32%, p<0.01) and hypoxia (CLPaer : -43±23%, p<0.01; CLPap : -41±20%, p<0.01). Hypoxia compared to normoxia increased cardiac output before (+23±19%, p<0.01 ANOVA) and during (+22±20%, p<0.01 ANOVA) IML, while local muscle perfusion during IML remained unchanged (CLPaer : p=0.41 ANOVA; CLPap : p=0.29 ANOVA).
CONCLUSION: Acute hypoxia compared to normoxia does not affect locomotor muscle perfusion during fatiguing IML.
METHODS: Ten subjects completed two study days of fatiguing IML (blinded, randomized) in normobaric hypoxia (targeted oxygen saturation 80%) and normoxia, respectively. Contrast-enhanced ultrasound (CEUS) of the gastrocnemius muscle and popliteal doppler ultrasonography were used to monitor muscle perfusion. Based on CEUS and monitored cardiac output, perfusion surrogate parameters (CLPaer and CLPap ) were established.
RESULTS: Muscle perfusion declines early during IML in normoxia (CLPaer : -54±25%, p<0.01; CLPap : -58±32%, p<0.01) and hypoxia (CLPaer : -43±23%, p<0.01; CLPap : -41±20%, p<0.01). Hypoxia compared to normoxia increased cardiac output before (+23±19%, p<0.01 ANOVA) and during (+22±20%, p<0.01 ANOVA) IML, while local muscle perfusion during IML remained unchanged (CLPaer : p=0.41 ANOVA; CLPap : p=0.29 ANOVA).
CONCLUSION: Acute hypoxia compared to normoxia does not affect locomotor muscle perfusion during fatiguing IML.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app