Analysis of mechanism of PM2.5 and house dust mite antigen Der p1 in attack stage of child asthma.

OBJECTIVE: We analyzed the influence of PM2.5 and house dust mite antigen Der p1 on the treatment of child asthma attack.

PATIENTS AND METHODS: A total of 96 children with asthma attack were included into the study. The patients were randomly divided into the PM2.5 group, the house dust mite antigen group, the synergistic group and the control group (n= 24 in each group).

RESULTS: The PM2.5 concentration in the PM2.5 group was twice higher than standard level (≤ the average value of PM2.5 in local air). All cases were given with same treatment, and the treatment effects were compared and analyzed. It was found that the asthma control rate in the control group was significantly higher than that in the PM2.5 group and the house dust mite antigen group, and the synergistic group was the lowest. The control time in the synergistic group was significantly longest, followed by the PM2.5 group and the house dust mite antigen group, and the control group was significantly short (p<0.05). After the intervention, the FVC, FEV1, and PEF levels were all increased. Those in control group were significantly higher than those of PM2.5 group and Dermatophagoides pteronyssinus group. Indicators in the collaborative group were the lowest. Differences were statistically significant (p<0.05). The differences in the PM2.5 group and Dermatophagoides pteronyssinus group were not statistically significant. The contents of serum IL-25, TSLP, and malondialdehyde after treatment of the control group significantly lowered while the other three groups showed a significant higher (p<0.05).

CONCLUSIONS: The PM2.5 and house dust mite antigen Der p1 can influence the treating effects of child asthma attack by an inflammatory reaction and oxidative stress.