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RESEARCH SUPPORT, N.I.H., EXTRAMURAL
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Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis.

Samuel J Landry, Daniel L Moss, Da Cui, Ryan P Ferrie, Mitchell L Fullerton, Evan A Wells, Lu Yang, Nini Zhou, Thomas Dougherty, Ramgopal R Mettu
Viral Immunology 2017 September
A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential processing may be at least partially responsible for variations in disease severity among arbo-flaviruses and points to structural features that modulate protection from disease.

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