[Effects of Danqi Capsule on Platelet Function in Healthy People].

OBJECTIVES: To study the effects of Danqi Capsule on platelet function in healthy people.

METHODS: Sixteen healthy volunteer were divided into low dose (4 capsules/time, 3 times/d) and high dose group (6 capsules/time, 3 times/d), and received Danqi Capsule by orally administration for 2 weeks. The venous blood were collect at 3 time points: one week before taking Danqi Capsule (control), one week after taking Danqi Capsule (1 week), two week after taking Danqi Capsule (2 weeks). Blood samples were used for the measurements of conventional coagulation examination, complete blood count, liver and kidney function test, platelet aggregation test, the plasma levels of P-selectin and von Willebrand factor (vWF) , and maximum aggregation (MA).

RESULTS: In both dosage group, Danqi capsule(1 week/2 weeks) administration showed no difference in conventional coagulation examination, complete blood count, liver and kidney function test, or the plasma level of vWF ( P >0.05), but showed difference (decreased) in platelet aggregation test and the plasma level of P-selectin (vs. control, P <0.05).

CONCLUSIONS: Danqi Capsule inhibits platelet activation and platelet aggregation, but not affects the plasma level of vWF, the coagulation function or the hepatorenal function in normal subjects.