We have located links that may give you full text access.
ENGLISH ABSTRACT
JOURNAL ARTICLE
[Pharmacokinetics of Curcumin Ethosomes in Rats in vitro].
Sichuan da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition 2017 March
OBJECTIVES: To study the oral phamacokinetics of curcumin ethosomes in rats.
METHODS: Pharmacokinetics parameters were detected by DAS 2.1.1 software analysis through data of blood concentrations harvested from HPLC after oral administration of curcumin ethosomes in rats.
RESULTS: Analyzed by non-compartmental method, the area under concentration-time curve from 0 to last time [AUC(0-72h)] of curcumin ethosomes was 1.6 times larger than that of free curcumin, the peak concentration (C max) of curcumin ethosomes was 1.5 times higher than that of free curcumin, the relative bioavailability of curcumin ethosomes was 152.2%. The 90% confidential interval of AUC(0-72 h)was 102.2%-128.5%, which was not in standard interval of bioequialence. Analyzed by compartmental method, the AUC(0-72 h)of curcumin ethosomes was 1.4 times larger than that of free curcumin and the relative bioavailability of curcumin ethosomes was 128.2%.
CONCLUSION: The curcumin ethosomes can enhance bioavailability, which has a bioinequivalence with free curcumin.
METHODS: Pharmacokinetics parameters were detected by DAS 2.1.1 software analysis through data of blood concentrations harvested from HPLC after oral administration of curcumin ethosomes in rats.
RESULTS: Analyzed by non-compartmental method, the area under concentration-time curve from 0 to last time [AUC(0-72h)] of curcumin ethosomes was 1.6 times larger than that of free curcumin, the peak concentration (C max) of curcumin ethosomes was 1.5 times higher than that of free curcumin, the relative bioavailability of curcumin ethosomes was 152.2%. The 90% confidential interval of AUC(0-72 h)was 102.2%-128.5%, which was not in standard interval of bioequialence. Analyzed by compartmental method, the AUC(0-72 h)of curcumin ethosomes was 1.4 times larger than that of free curcumin and the relative bioavailability of curcumin ethosomes was 128.2%.
CONCLUSION: The curcumin ethosomes can enhance bioavailability, which has a bioinequivalence with free curcumin.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app