Add like
Add dislike
Add to saved papers

Analysis of cervical lesions for presence of HSV-2 and HPV-16 and HPV-18 in Iranian patients by PCR.

Objective Cervical cancer (CC) is one of the leading causes of deaths from cancer among women worldwide. Viral infections is now one of the known risk factors for CC. The aim of this study was to investigate the presence of herpes simplex virus type 2 (HSV-2), human papilloma virus types 16 (HPV-16) and human papilloma virus types 18 (HPV-18) in Iranian patients with CC using the polymerase chain reaction (PCR). Materials and methods This case-control study was conducted on a total of 45 patients with CC from Khatam-Al-Anbiya Hospital, Hamadan, Iran during 2014, and 30 samples from healthy subjects as controls. The presence of HSV-2 and HPV-16/18 DNA sequences was detected by PCR. Results Eight of CC patients (17.77%) had HPV-16/18 DNA and only one patient (2.22%) with HSV-2 was identified. These viruses were not detected in control cases. Among HPV-16/18 positive patients, 62.5% and 37.5% biopsies were positive for HPV-16 and HPV-18, respectively. On the other hand, only one case (2.22%) was positive for HPV-16/18, but HSV-2 and this co-infection was not detected in the control group. Conclusion Our results demonstrate that there was no direct molecular evidence to support a cofactor relationship between HSV-2 and HPV-16/18 in cervical malignancies. However, the results about HPV-16/18 was in accordance with previous studies.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app