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Pre-acclimation to low copper mitigated immunotoxic effects in spleen and head-kidney of large yellow croaker (Pseudosciaena crocea) when exposed subsequently to high copper.
Ecotoxicology and Environmental Safety 2017 October
The hypothesis tested in this study was that Cu pre-acclimation would mitigate high Cu induced immunotoxic effects in large yellow croaker Pseudosciaena crocea. To the end, fish were pre-acclimation to 0 and 84μg CuL(-1) for 48h and then exposed to 0 and 420μg CuL(-1) for another 48h. Survival rate, Cu content, ROS, NO, activities and mRNA levels of inflammatory genes (iNOS and COX-2), and gene expressions of transcription factor NF-κB and its inhibitor IκBα were determined in spleen and head-kidney of large yellow croaker. Cu pre-acclimation significantly reduced mortality of fish exposed to 420μg CuL(-1). Cu pre-acclimation triggered the up-regulation of both enzyme activities and express levels of iNOS and COX-2 in spleen under 420μg CuL(-1) exposure, resulting in remarkable reduction of Cu content and ROS in this tissue. Contrast to spleen, iNOS activity remained unchanged but the mRNA level of iNOS increased, and the mRNA level of COX-2 remained constant though COX-2 activity enhanced in head-kidney, suggesting iNOS and COX-2 may be modulated by Cu at a post-transcriptional level. In this process, NF-κB/IκBα signaling molecules may play a vital role in the transcriptional activation of inflammatory genes in both spleen and head-kidney. In conclusion, low Cu pre-acclimation alleviated high Cu induced immunotoxicity in spleen and head-kidney of large yellow croaker by enhancing the activities and mRNA levels of inflammatory genes.
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