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Vancomycin Taper and Pulse Regimen With Careful Follow-up for Patients With Recurrent Clostridium difficile Infection.

Benjamin D Sirbu, Melinda M Soriano, Carl Manzo, Jessica Lum, Dale N Gerding, Stuart Johnson
Clinical Infectious Diseases 2017 October 16
We retrospectively studied vancomycin taper and pulse treatment on 100 consecutive, evaluable patients with recurrent Clostridium difficile infection. Following taper to once-daily vancomycin dosing, 22 of 36 patients (61%) who received every-other-day dosing (QOD) and 50 of 64 (81%) who received QOD followed by every-third-day dosing were cured (P = .03).

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