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Triglyceride Metabolism under Attack.
Cell Metabolism 2017 June 7
Hydrolysis of circulating triglycerides is carried out by the enzyme lipoprotein lipase, which is transported and anchored to the capillary wall by the protein GPIHBP1. Recent evidence indicates that certain individuals develop autoantibodies against GPIHBP1, impairing lipoprotein lipase function and leading to markedly elevated plasma triglyceride levels (Beigneux et al., 2017).
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