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"Chronic myelogenous leukemia in primary blast crisis" rather than "de novo BCR-ABL1 -positive acute myeloid leukemia".
Clinical Case Reports 2017 June
Differentiating chronic myelogenous leukemia in primary blast crisis (CML-BC) from de novo BCR-ABL1 -positive acute myeloid leukemia (AML) is a diagnostic challenge with therapeutic consequences. In our case, a basophilia, the presence of the Philadelphia chromosome in all metaphases and the strict exclusion of molecular hallmarks of AML lead us to retain the diagnosis of CML-BC rather than BCR-ABL1+ AML.
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