Psychopharmacological Effects of JNK Inhibitor in Posthypoxic Encephalopathy and Mechanisms of Their Development.

G N Zyuz'kov, N I Suslov, T N Povet'eva, Yu V Nesterova, O G Afanas'eva, E V Udut, L A Miroshnichenko, E V Simanina, T Yu Polyakova, L A Stavrova, A V Chaikovskii, P V Kul'pin, V V Udut, A M Dygai, V V Zhdanov

Bulletin of Experimental Biology and Medicine 2017 May

Psychopharmacological effects of JNK inhibitor were studied using a mouse model of posthypoxic encephalopathy. The preparation exhibited a pronounced cerebroprotective effect manifested in normalization of orientation and exploratory behavior and conditioned responses in posthypoxic mice. These effects were accompanied by marked elevation of neural stem cell content in the paraventricular region of the brain.

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