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SUMO Teams Up with a Translocase to Save TOPO.

Nalini Dhingra, Xiaolan Zhao
Molecular Cell 2017 June 2
In this issue of Molecular Cell, Wei et al. (2017) report how a DNA translocase uses SUMO as a cue to save Top2 from ubiquitin-mediated degradation and to minimize DNA breaks, thus providing insights into the SUMO and ubiquitin interplay in genome maintenance.

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