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Journal Article
Research Support, Non-U.S. Gov't
Thermal annihilation of photo-induced radicals following dynamic nuclear polarization to produce transportable frozen hyperpolarized 13 C-substrates.
Nature Communications 2017 June 2
Hyperpolarization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time 13 C MRI. The type of applications is however limited by the relatively fast decay time of the hyperpolarized spin state together with the constraint of having to polarize the 13 C spins in a dedicated apparatus nearby but separated from the MRI magnet. We herein demonstrate that by polarizing 13 C with photo-induced radicals, which can be subsequently annihilated using a thermalization process that maintains the sample temperature below its melting point, hyperpolarized 13 C-substrates can be extracted from the DNP apparatus in the solid form, while maintaining the enhanced 13 C polarization. The melting procedure necessary to transform the frozen solid into an injectable solution containing the hyperpolarized 13 C-substrates can therefore be performed ex situ, up to several hours after extraction and storage of the polarized solid.
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