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Blood-brain barrier peptide shuttles.

Macarena Sánchez-Navarro, Ernest Giralt, Meritxell Teixidó
Current Opinion in Chemical Biology 2017 June
Brain delivery is hampered by the presence of the blood-brain barrier (BBB), a natural defence of the brain that protects it and allows the entrance of nutrients by several mechanisms. Taking advantage of these mechanisms is an opportunity to treat brain related diseases. Among the different alternatives, BBB peptide shuttles are gaining attention to increase brain delivery of therapeutics. The most recent advances in the field are analysed here.

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