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Initial Clinical Experience with (68)Ga-DOTA-NOC Prepared Using (68)Ga from Nanoceria-polyacrylonitrile Composite Sorbent-based (68)Ge/(68)Ga Generator and Freeze-dried DOTA-NOC Kits.
World Journal of Nuclear Medicine 2017 April
Somatostatin receptor positron emission tomography-computed tomography (PET/CT) with (68)Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine tumors and forms the basis of personalized therapy with peptide receptor-based radionuclide therapy. With growing utilization of PET/CT in developing countries, availability of the indigenous GMP-certified (68)Ge/(68)Ga generators is expected to further promote cost-effective molecular imaging service to the cancer patients. We present our initial clinical experience in 32 patients injected with (68)Ga-DOTA-NOC prepared using (68)Ga eluted from Bhabha Atomic Research Centre nanoceria-polyacrylonitrile sorbent-based (68)Ge/(68)Ga generator and freeze-dried DOTA-NOC cold kits.
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