JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Add like
Add dislike
Add to saved papers

Role of transcriptional bursts in cellular oscillations.

Genetic oscillators are present in the cells of many organisms and control several biological processes. The common feature of such oscillators is the presence of a protein which represses the transcription of its own gene. Recently, it has been shown that for many genes transcription is not a continuous process, but that it proceeds in bursts. We study here the relationship between bursty transcription and the robustness of protein oscillations. We concentrate on the temporal profile of mRNA production by studying regimes where this profile changes but the amount of mRNA produced is kept fixed. For systems with different degrees of cooperativity we show that in general bursts are associated with more robust oscillations, but when they are too short and intense they can have the opposite effect. In other words, we show that, in terms of the regularity of the oscillations generated, there is an optimal value for the intensity of the bursts.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app