We have located links that may give you full text access.
Secondary Sulfonamides as Effective Lactoperoxidase Inhibitors.
Secondary sulfonamides ( 4a - 8h ) incorporating acetoxybenzamide, triacetoxybenzamide, hydroxybenzamide, and trihydroxybenzamide and possessing thiazole, pyrimidine, pyridine, isoxazole and thiadiazole groups were synthesized. Lactoperoxidase (LPO, E.C.1.11.1.7), as a natural antibacterial agent, is a peroxidase enzyme secreted from salivary, mammary, and other mucosal glands. In the present study, the in vitro inhibitory effects of some secondary sulfonamide derivatives ( 4a - 8h ) were examined against LPO. The obtained results reveal that secondary sulfonamide derivatives ( 4a - 8h ) are effective LPO inhibitors. The Ki values of secondary sulfonamide derivatives ( 4a - 8h ) were found in the range of 1.096 × 10-3 to 1203.83 µM against LPO. However, the most effective inhibition was found for N -(sulfathiazole)-3,4,5-triacetoxybenzamide ( 6a ), with Ki values of 1.096 × 10-3 ± 0.471 × 10-3 µM as non-competitive inhibition.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app