[A Case of Late Recurrence of Breast Cancer Causing Multiple Organ Metastases 27 Years Postoperatively].

The patient was a 77-year-old female with a history of treatment for cancer of the right breast 27 years earlier, who presented with a chief complaint of a subcutaneous mass in the left lower quadrant of her abdomen. A thorough examination revealed high breast cancer-related tumor marker values, and based on a computed tomography(CT)examination, a tentative diagnosis of multiple lung, liver, retroperitoneal, and abdominal wall metastases was made. Although there were multiple organ metastases, in view of the long interval before the recurrence, absence of any symptoms, and the patient's age, we initiated treatment by weekly administration of an aromatase inhibitor and trastuzumab. The treatment was effective; the multiple metastases regressed, and the tumor marker levels decreased. One year after the start of treatment, the patient had a rebound in the tumor marker levels, and an increase in the size of the liver metastases was observed in diagnostic images. The aromatase inhibitor was discontinued and replaced with high-dose toremifene citrate, and trastuzumab was administered every other week. This regimen achieved efficacy, and the liver metastases regressed. As of 2years since the start of the initial treatment, no progression of the metastases has been observed, and the patient continues to be treated with the same regimen.