ABCB1-C3435T polymorphism and breast cancer risk: a case-control study and a meta-analysis.

PURPOSE: To investigate the association of ABCB1-C3435T transition with breast cancer risk which was followed by a meta-analysis.

METHODS: In a case-control study we collected blood samples from 290 women (including 150 breast cancer patients and 140 healthy controls). ABCB1-C3435T genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A meta- analysis was performed for a total of 13 eligible studies involving 5,835 cases and 8,178 controls.

RESULTS: The results of case-control study revealed a significant association between T allele (OR=1.770, 95% CI=1.236- 2.535, p=0.002), CT genotype (OR=1.661, 95% CI=1.017- 2.713, p=0.042), and TT genotype (OR=3.399, 95% CI=1.409- 8.197, p=0.006) with breast cancer risk. Data from meta- analysis revealed a significant association between ABCB1-C3435T polymorphism and breast cancer risk in allelic (OR=1.243, 95% CI=1.079-1.432, p=0.003), co-dominant (OR=1.349, 95% CI=1.042-1.746, p=0.023), dominant (OR=1.204, 95% CI=1.019-1.422, p=0.029), and recessive (OR=1.226, 95% CI=1.011-1.488, p=0.039) models.

CONCLUSIONS: The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.